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KMID : 0363420080220030083
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Journal of Korean Oriental Pediatrics
2008 Volume.22 No. 3 p.83 ~ p.94
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A Clinical Study on the Modified RUCAM Application to Liver Injury Induced by Herbal Medicine
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Cheon Jin-Hong
Min Sang-Yeon
Kim Jang-Hyun
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Abstract
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Objectives: The purpose of this study is to confirm severe problem caused by using a modified RUCAM scale than that officially recognized to diagnose liver injury induced by herbal medicine.
Materials and Methods: Cases with liver injury induced by herbal medicine received to a related institute from January 2004 to December 2007 were collected and evaluated by the original scale and modified scale.
Results: 1. Based on this study, we couldn’t clinicaly confirm that the case was not excluded by the relieved first item basis of modified RUCAM scale which has to be excluded by the first item basis of orginal RUCAM scale. 2. By modified 6th item, one score was added to the total score. 3. By adding 8th item, it gaind one point to the whole the total score.
Conclusions: In this study, we can clinically confirm that the modified RUCAM application to case with liver injury induced by herbal medicine is a severe problem.
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KEYWORD
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drug-induced liver injury, hepatotoxicity, herbal medicine, RUCAM, modified RUCAM
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